In the traditional approach to cut point determination (here referred to as the outlier approach), analytical (intra-subject) and biological (inter-subject) outliers are removed from the dataset based on the Tukey Outlier test using the interquartile range. The new resulting distribution is then used to determine a cut point, using parametric method for normal/log-normal distributed data and nonparametric method for other types of distributions. Learn more in this app note.
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